The Katzen Collection is a private collection from Dr. Cyrus and Myrtle Katzen. It was donated to the university in 2005. The collection is comprised of more than 300 artworks, including paintings, prints, drawings, and sculpture. The Katzen Collection focuses on several areas, including Pop Art, Washington art, and glass sculpture. Larry Rivers, Red Grooms, and Roy Lichtenstein are prominent in the collection, as well as Washington artists Gene Davis, Sam Gilliam, and Bill Willis. The Katzen Collection also contains three large bronze sculptures by Nancy Graves, one of which is a working clock.

This extraordinary gift was inspired by Myrtle Katzen's love of the art department which she discovered through taking classes at the university. She found great support in painting with a group of alumni artists in the AU studios. Cyrus Katzen, who graduated from Georgetown University's School of Dentistry in 1941, became a supporter of the university through his close friendship with former AU President Benjamin Ladner and Vice President Don Myers. "The art in our collection makes you smile and laugh," Cy Katzen says.